Medicinal Chemistry, Drug Synthesis

More than 40% of the chemical scaffolds found in natural products are absent in now-a-days medicinal chemistry repertoire. Based on various chemical properties, combinational compounds occupy a much smaller area in molecular space than natural products. Natural products undergo primary metabolites and secondary metabolites, Natural products under go biosynthesis and produce carbohydrates and fatty acids and polyketides. Their main sources are from prokaryotic, bacteria, archaea, eukaryotic, fungi, plants, animals.  A cyclic organic compound containing all carbon atoms in ring formation is referred to as a carbocyclic compound. If at least one atom other than carbon forms a part of the ring system then it is designed as a hetero-cyclic compound. Nitrogen, oxygen and sulfur are the most common heteroatoms but heterocyclic rings containing other hetero atoms are also widely known. An enormous number of heterocyclic compounds may be classified into aliphatic and aromatic. Heterocyclic ring may comprise of three or more atoms which may be saturated or unsaturated. Also the ring may contain more than one hetero atom which may be similar or dissimilar.

Drug Synthesis deals with the synthesis of drugs either from natural origin or from chemicals, which converts inactive chemical into active drug.

  • Pharmaceutical Sciences
  • Drug Design and Drug Development
  • CADD (Computer Aided Drug Design)
  • Pharmacology and toxicology
  • Anticancer agents
  • Pharmaceutical Industry
  • Pharmacognosy and Pharmacokinetics
  • Pharmacophore and Xenobiotic metabolism
  • Drug discovery
  • Hit to lead and lead optimization

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